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Effects of leptin replacement in adults. (a) Effects of r-metHuLeptin on weight in three leptin-deficient adults. Arrow indicates the start of r-metHuLeptin therapy. (b) Effects of r-metHuLeptin on energy intake in leptin-deficient adults. (c) Dose of s.c. r-metHuLeptin used in the three leptin-deficient adults.
