Table 1. Effects of leptin replacement therapy on body composition.
| Months of treatment
|
||||||
|---|---|---|---|---|---|---|
| Measurement | Patient | 0 (baseline) | 3 | 6 | 18 | Significance* |
| Body weight, kg | A | 134.1 | 118.4 | 99.7 | 64.3 | |
| B | 108.4 | 89.2 | 77.9 | 60.4 | P < 0.05 | |
| C | 132.4 | 116.6 | 101.3 | 74.3 | ||
| Fat mass, kg | A | 58.6 | 50.8 | 33.1 | 6.5 | |
| B | 52.0 | 41.2 | 27.8 | 14.4 | P < 0.02 | |
| C | 64.9 | 54.9 | 44.6 | 25.8 | ||
| Fat-free mass, kg | A | 75.5 | 67.6 | 63.6 | 57.8 | |
| B | 56.4 | 48.0 | 50.1 | 46.0 | P < 0.03 | |
| C | 67.5 | 61.7 | 56.7 | 48.5 | ||
| Body fat, % | A | 43.8 | 43.6 | 34.2 | 10.1 | |
| B | 47.9 | 46.2 | 36.2 | 23.8 | P < 0.05 | |
| C | 49.5 | 47.1 | 44.0 | 34.7 | ||
*
Paired comparisons from month 0 to month 18 for mean of the three patients.