Table 2. Effects of leptin replacement on metabolic parameters.

		Months of treatment
Parameter	Patient	0	2	4	6	8	18
Fasting glucose, mg/dl	A	91	89	88	85	75	78
	B	88	93	82	89	81	84
	C	131	143	120	116	105	86
Fasting insulin, microunits/ml*	A	4.8	5.2	4.0	3.1	2.3	1.8
	B	3.8	4.4	3.2	4.0	2.1	1.8
	C	7.5	14	7.7	4.4	4.9	3.1
Fasting C-peptide, ng/ml*	A	2.2	2.5	1.7	1.2	0.8	0.5
	B	2.0	1.6	1.0	1.4	0.5	0.6
	C	4.0	4.0	4.3	2.6	2.1	1.2
Total cholesterol, mg/dl	A	137	124	107	111	114	96
	B	115	117	106	109	99	110
	C	181	160	134	147	125	125
HOMA-IR†	A	1.08	1.14	0.87	0.65	0.43	0.35
	B	0.83	1.01	0.65	0.89	0.42	0.37
	C	2.43	4.94	2.28	1.26	1.30	0.66
Triglycerides, mg/dl	A	125	82	67	72	60	69
	B	79	66	53	57	27	47
	C	247	225	165	148	127	115
HDL cholesterol, mg/dl	A	29.9	45.7	33.1	29.9	32.7	53.3
	B	36.8	36.8	37.6	40.3	44.2	51.2
	C	28.6	27.5	24.5	31.3	32.7	38.4
LDL cholesterol, mg/dl	A	82	62	61	67	69	29
	B	62	67	58	57	49	49
	C	103	88	77	86	67	64
Apolipoprotein A1, mg/dl	A	88	98	71	74	76	82
	B	81	83	81	90	83	94
	C	88	100	81	85	82	89
Apolipoprotein B, mg/dl	A	83	68	54	59	61	50
	B	57	58	54	54	42	47
	C	114	113	89	80	67	68

^*P < 0.05 for paired comparisons from month 0 to month 18 for mean of the three patients.

^†HOMA-IR = fasting insulin (microunits/ml) × fasting glucose (mmol/liter)/22.5.