Table 2. Effects of leptin replacement on metabolic parameters.
Months of treatment
|
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---|---|---|---|---|---|---|---|
Parameter | Patient | 0 | 2 | 4 | 6 | 8 | 18 |
Fasting glucose, mg/dl | A | 91 | 89 | 88 | 85 | 75 | 78 |
B | 88 | 93 | 82 | 89 | 81 | 84 | |
C | 131 | 143 | 120 | 116 | 105 | 86 | |
Fasting insulin, microunits/ml* | A | 4.8 | 5.2 | 4.0 | 3.1 | 2.3 | 1.8 |
B | 3.8 | 4.4 | 3.2 | 4.0 | 2.1 | 1.8 | |
C | 7.5 | 14 | 7.7 | 4.4 | 4.9 | 3.1 | |
Fasting C-peptide, ng/ml* | A | 2.2 | 2.5 | 1.7 | 1.2 | 0.8 | 0.5 |
B | 2.0 | 1.6 | 1.0 | 1.4 | 0.5 | 0.6 | |
C | 4.0 | 4.0 | 4.3 | 2.6 | 2.1 | 1.2 | |
Total cholesterol, mg/dl | A | 137 | 124 | 107 | 111 | 114 | 96 |
B | 115 | 117 | 106 | 109 | 99 | 110 | |
C | 181 | 160 | 134 | 147 | 125 | 125 | |
HOMA-IR† | A | 1.08 | 1.14 | 0.87 | 0.65 | 0.43 | 0.35 |
B | 0.83 | 1.01 | 0.65 | 0.89 | 0.42 | 0.37 | |
C | 2.43 | 4.94 | 2.28 | 1.26 | 1.30 | 0.66 | |
Triglycerides, mg/dl | A | 125 | 82 | 67 | 72 | 60 | 69 |
B | 79 | 66 | 53 | 57 | 27 | 47 | |
C | 247 | 225 | 165 | 148 | 127 | 115 | |
HDL cholesterol, mg/dl | A | 29.9 | 45.7 | 33.1 | 29.9 | 32.7 | 53.3 |
B | 36.8 | 36.8 | 37.6 | 40.3 | 44.2 | 51.2 | |
C | 28.6 | 27.5 | 24.5 | 31.3 | 32.7 | 38.4 | |
LDL cholesterol, mg/dl | A | 82 | 62 | 61 | 67 | 69 | 29 |
B | 62 | 67 | 58 | 57 | 49 | 49 | |
C | 103 | 88 | 77 | 86 | 67 | 64 | |
Apolipoprotein A1, mg/dl | A | 88 | 98 | 71 | 74 | 76 | 82 |
B | 81 | 83 | 81 | 90 | 83 | 94 | |
C | 88 | 100 | 81 | 85 | 82 | 89 | |
Apolipoprotein B, mg/dl | A | 83 | 68 | 54 | 59 | 61 | 50 |
B | 57 | 58 | 54 | 54 | 42 | 47 | |
C | 114 | 113 | 89 | 80 | 67 | 68 |
P < 0.05 for paired comparisons from month 0 to month 18 for mean of the three patients.
HOMA-IR = fasting insulin (microunits/ml) × fasting glucose (mmol/liter)/22.5.