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Overall pipeline of upstream regulator inference. (A) Global regulatory network modeling using ARACNE. (B) Regulon extraction for each TF. (C) Master regulator analysis (MRA) selects the TFs showing a significant overlap with the prognostic signature genes (D) Extraction of top 10 TFs by the signature coverage of MRA derived regulons (E) Stepwise linear regression (SLR) for edge filtering and extraction of top 10 TFs by the signature coverage of MRS + SLR derived regulons.
