Table 1. ELISA and neutralization titers.
| Reciprocal endpoint ELISA titer
|
IC50 neutralization titer
|
|||||||
|---|---|---|---|---|---|---|---|---|
| IMV
|
L1
|
A33
|
||||||
| Immunization | 3 wk | 6 wk | 3 wk | 6 wk | 3 wk | 6 wk | 3 wk | 6 wk |
| None | < 100 | < 100 | < 100 | < 100 | < 100 | < 100 | < 50 | < 50 |
| 108 pfu MVA* | 6,400 | 102,400 | 6,400 | 51,200 | 1,600 | 51,200 | 583 | 12,130 |
| 107 pfu MVA* | 800 | 25,600 | 1,600 | 12,800 | 800 | 25,600 | 139 | 2,835 |
| 106 pfu MVA* | 200 | 6,400 | 200 | 3,200 | < 100 | 3,200 | < 50 | 1,046 |
| 5 × 105 pfu Dryvax† | 6,400 | 25,600 | 1,600 | 12,800 | 1,600 | 3,200 | 1,181 | 6,323 |
Eight mice were immunized at 0 time and bled on week 3; four mice were reimmunized on week 4 and bled on week 6.
Eight mice were immunized at 0 time and bled on week 3; four mice were bled on week 6.