Table 5.

Drug-drug interactions for the approved oral multiple sclerosis drugs^1,3,4

Drug interaction	Dimethyl fumaratea	Fingolimod	Teriflunomide
Antineoplastic, immunosuppressive, or immunomodulating therapies		X
CYP1A2 substrates (eg, duloxetine, alosetron, theophylline, tizanidine)			X
CYP2C8 substrates (eg, repaglinide, paclitaxel, pioglitazone, rosiglitazone)			X
Drugs that slow heart rate or atrioventricular conduction (eg, beta-blockers, diltiazem)		X
Ketoconazole		X
Oral contraceptives			X
QT-prolonging drugs (eg, citalopram, chlorpromazine, haloperidol, methadone, erythromycin)		X
Vaccines		X	X
Warfarin			X

^aNone reported in the product labeling for dimethyl fumarate.