FIG. 2.

Anti-AAVrh.10 neutralizing antibodies evoked by CNS administration of AAVrh.10hCLN2 to nonhuman primates. Titers were assessed in serum by neutralization of in vitro gene transfer assay. Titers (average of two determinations) were evaluated presurgery (“presurgery” is defined as any time from 24 hr to 2 months before day 0, the day of surgery), and on days 7, 15, 30, and 60 postsurgery. Shown are data from treated animals killed on days 7 and 90 and the PBS control animal killed on day 7.