Table 1.

Participant characteristics, stratified by HCV and HIV infection status

	HCV/HIV Infection Status
	Uninfected (n=166)	HCV-monoinfected (n=703)	HCV/HIV-coinfected (n=322)	p-valuea
Age, mean [SD]	42.9 [7.9]	47.6 [8.3]	46.8 [6.4]	<0.001
Female sex	40.4	33.7	36.0	0.26
African Americanb	89.2	84.5	93.5	<0.001
Married, ever	27.1	40.2	27.2	<0.001
Employedc	31.3	27.3	20.2	0.012
Homelessc	13.9	16.8	14.3	0.49
Cigarette usec	83.7	85.8	81.9	0.27
Alcohol use, ≥1 day/weekc	61.5	55.2	45.5	0.001
Injection drug use intensityc
None	61.5	50.5	57.8	0.001
<Daily	21.7	24.5	27.3
≥Daily	16.9	25.0	14.9
Depressive symptoms	25.9	21.6	26.5	0.17
No. of comorbiditiesd, median [IQR]	1 [0, 1]	1 [0, 2]	2 [1, 3]	<0.001
Chronic kidney disease	9.7	20.8	49.8	<0.001
Anemia	14.5	20.2	37.0	<0.001
Diabetes	8.4	8.7	7.1	0.73
Hypertension	31.7	42.8	37.2	0.020
Liver fibrosis	12.3	29.9	40.8	<0.001
Obstructive lung disease	16.6	15.6	16.5	0.92
BMI
<25	45.2	44.5	54.1	0.019
25–30	26.8	33.1	27.7
≥30	28.0	22.3	18.2
IL−6 (pg/ml), median [IQR]	1.37 [0.90, 2.26]	1.56 [0.98, 2.78]	1.82 [1.21, 3.15]	0.002
CRP (mg/l), median [IQR]	2.13 [0.94, 5.57]	1.56 [0.53, 4.82]	1.36 [0.51, 3.88]	0.003

Abbreviations: SD = standard deviation, IQR = interquartile range, HCV = hepatitis C virus, HIV = human immunodeficiency virus, BMI = body mass index

All values given as percentages unless otherwise indicated.

^ap-values comparing determined using Fisher’s exact tests for categorical variables and analysis of variance for continuous variables (normal distribution) or Hodges-Lehmann’s tests on equality of medians for continuous variables (non-normal distribution).

^bAfrican American race is in comparison to white/other which is 81% white, 12% other, and 7% Asian, Alaskan/Native American, and white Hispanic.

^cIn prior 6 months.

^dComorbidities include a summary score of chronic kidney disease, anemia, diabetes, hypertension, liver fibrosis, and obstructive lung disease.