Table 1.
Effect of GK-2 on the impairment of EOR extinction during the open-field test caused by transsection of the septo-hippocampal pathway
| Group | min 1 | min 2 | min 3 | min 4 | Extinction coefficient |
|---|---|---|---|---|---|
| Sham surgery | 21(15–32) | 14(11–25) | 9.5(7–16)* | 9(8–13)* | 2.3 |
| Surgery | 11.5(8–35) | 12(9–32) | 19(11–24) | 11.5(9–29) | 1 |
| Surgery + GK-2 | 12.5(9–21) | 11.5(7–14) | 15.5(8–17) | 6.5(3–8)* | 1.9 |
* p < 0.05 as compared to the locomotor activity in the same group during the first minute of the test. Note. The data are presented as medians of respective samples. The extinction coefficient (Ce) of the EOR reflecting the ability of rats to habituate was calculated using the equation Ce= a/b, where a is the number of squares crossed in the group during the first minute of observation, and b is the number of squares crossed in the group during the last minute of observation.