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. 2004 Mar 15;101(13):4695–4700. doi: 10.1073/pnas.0306931101

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Fig. 3. — Effects of high-fat feeding in Pomc^-/-, Pomc^+/-, and wild-type mice. (A) On a high-fat diet, Pomc^-/- mice are significantly heavier at 8 weeks (^*, P < 0.05) and attain a greater adult body weight compared with wild-type mice (wild-type, n = 10, Pomc^+/-, n = 10; Pomc^-/-, n = 4). ^***, P < 0.001. Pomc^+/- mice also develop obesity on a high-fat diet compared with wild-type mice by 20 weeks (^*, P < 0.05). (B) Food intake of individually housed 2-month-old male mice maintained on a high-fat diet (n = 4 for each group). Pomc^-/- and Pomc^+/- vs. wild-type mice, ^*, P < 0.05.