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. 2013 Nov 28;19(44):7930–7946. doi: 10.3748/wjg.v19.i44.7930

Table 2.

Pathogenesis of maldigestion

Mechanism Explanation
Decreased pancreatic production Lack of functional tissue or decreased endogenous neurohormonal stimulation
Decrease in delivery Pancreatic duct obstruction
Decreased activation Low duodenal pH
Premature enzymatic degradation Decreased contact time due to increased motility, impaired interaction with chyme and biliary salts, and intestinal bacterial overgrowth