Table 2.
Mechanism | Explanation |
Decreased pancreatic production | Lack of functional tissue or decreased endogenous neurohormonal stimulation |
Decrease in delivery | Pancreatic duct obstruction |
Decreased activation | Low duodenal pH |
Premature enzymatic degradation | Decreased contact time due to increased motility, impaired interaction with chyme and biliary salts, and intestinal bacterial overgrowth |