Table 4.

Results of meta-analysis comparing laparoscopic total gastrectomy vs open total gastrectomy

Outcome of interest	No. of studies	No. of patients	OR/WMD	95%CI	P value	Heterogeneity P value	I2
Operative outcomes
Operation time (min)	15	2022	48.25	31.15-65.35	< 0.00001	< 0.00001	93%
Intraoperative blood loss (mL)	12	1168	-201.19	-296.50--105.87	< 0.0001	< 0.00001	98%
Postoperative recovery
Time to first flatus (d)	12	1412	-0.82	-1.18--0.45	< 0.0001	< 0.00001	90%
Time to first oral intake (d)	8	1266	-1.3	-1.84--0.75	< 0.00001	< 0.00001	82%
Hospital stay (d)	13	1786	-3.55	-5.13--1.96	< 0.0001	< 0.00001	86%
Analgesics use (times)	5	730	-0.09	-2.39-2.20	0.94	0.0008	79%
Postoperative complications
Overall complication	14	1983	0.73	0.57-0.92	0.009	0.08	37%
Anastomotic leakage	14	1983	1.6	0.88-2.91	0.12	0.68	0%
Anastomotic stenosis	13	1923	1.22	0.68-2.21	0.50	0.95	0%
Ileus	13	1923	1.26	0.69-2.30	0.46	0.85	0%
Bleeding	13	1923	1.42	0.70-2.87	0.33	0.26	23%
Abdominal abscess	13	1923	0.53	0.28-1.03	0.06	0.37	8%
Wound problems	13	1923	0.39	0.21-0.72	0.002	0.75	0%
Oncological outcomes
Positive resection margins	5	698	0.57	0.03-9.55	0.69	-	-
No. of resected lymph nodes	14	1962	-2.49	-5.18-0.21	0.07	< 0.00001	74%
Proximal resection margin (cm)	4	1160	-0.26	-0.54-0.01	0.06	0.65	0%
Distal resection margin (cm)	4	1160	0.32	-0.05-0.68	0.09	0.22	32%