Table 5. Physicochemical evaluation of 300 mg effervescent ranitidine HCl tablets by direct compression method (Mean ± SD).
| Physicochemical evaluation | Formulations | |||||
| F1 | F2 | F3 | F4 | F5 | F6 | |
| Weight variation (%) | 1.95±0.04 | 2.32±0.04 | 1.76±0.05 | 1.12±0.08 | 1.08±0.05 | 1.30±0.04 |
| Friability test (%) | 0.78±0.10 | 0.89±0.18 | 0.78±0.18 | 0.84±0.22 | 0.57±0.13 | 0.43±0.13 |
| Thickness (mm) | 5.08±0.03 | 5.73±0.04 | 5.18±0.05 | 5.23±0.08 | 5.50±0.01 | 5.75±0.06 |
| Hardness (N) | 58±8.50 | 42±6.46 | 59±4.12 | 47.5±3.30 | 65±4.28 | 66±6.43 |
| pH | 5.36±0.03 | 5.02±0.02 | 5.85±0.02 | 5.38±0.01 | 6.1±0.04 | 5.94±0.02 |
| Effervescence time (sec) | 98±1.53 | 82±3 | 82±2.50 | 67±3.61 | 90±4.04 | 83±3.79 |
| CO2 content (mg) | 239±1 | 240±0.58 | 244±1.53 | 247±1.16 | 248±0.58 | 250±1.15 |
| Assay (mg) | 340±0.02 | 330.3±0.05 | 341.4±0.04 | 336.7±0.02 | 336±0.01 | 335±0.04 |
| Content uniformity (%) | 99.4±3.55 | 99.2±4.15 | 100±4.92 | 100.1±2.96 | 100.1±3.94 | 99.5±5.02 |
| Water content (%w/w) | 0.14±0.006 | 0.18±0.012 | 0.17±0.007 | 0.14±0.007 | 0.20±0.003 | 0.16±0.009 |