Table 3.

EGFR and KRAS point mutations, deletions, and insertions in never smoking lung cancer tumors

Gene	Event	Description	Histology	Differentiation	Age	Fuel Used for Heating and Cooking**
EGFR
	Point Mutation
		EGFR_G719A_2156G>C*	Adenocarcinoma	Well	40	Only Coal
		EGFR_L858R_2573T>G	Adenocarcinoma	Well	40	Only Coal
		EGFR_G719C_2155G>T	Adenocarcinoma	Well	56	Only Coal
		EGFR_G719A_2156G>C	Adenocarcinoma	Moderately	52	Only Coal
		EGFR_G719C_2155G>T	Adenocarcinoma	Moderately	52	Only Coal
		EGFR_L858R_2573T>G	Adenocarcinoma	Moderately	58	Only Coal
		EGFR_G719S _2155G>T	Adenocarcinoma	Poorly	30	Only Coal
		EGFR_G719S_2155G>A	Adenocarcinoma	Poorly	40	Only Coal
		EGFR_G719C_2155G>T	Squamous Cell Carcinoma	Moderately	58	Only Coal
	Deletion
		EGFR_19-15bpDel	Adenocarcinoma	Moderately	43	Only Coal
		EGFR_19-15bpDel	Adenocarcinoma	Moderately	52	Unknown
		EGFR_19-15bpDel	Adenocarcinoma	Moderately	58	Coal and Wood
		EGFR_19-15bpDel	Squamous Cell Carcinoma	Moderately	50	Electric
	Insertion
		E20-6bp-ins.	Adenocarcinoma	Moderately	50	Only Coal
KRAS
	Point Mutation
		KRAS(R)G12C_34G>T	Adenocarcinoma	Moderately	30	Only Coal
		KRAS(R)G12C_34G>T	Adenocarcinoma	Moderately	40	Only Coal
		KRAS(R)G12C_34G>T	Adenocarcinoma	Moderately	50	Only Coal
		KRAS(R)G12C_34G>T	Adenocarcinoma	Moderately	52	Only Coal
		KRAS(R)G12C_34G>T	Adenocarcinoma	Moderately	52	Only Coal
		KRAS(R)G12C_34G>T	Squamous Cell Carcinoma	Poorly	24	Only Coal

^*This tumor also had a second EGFR point mutation [EGFR(R)L861Q_2582T>A]

^**Type of fuel currently used at the time of surgery