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. Author manuscript; available in PMC: 2014 Dec 19.
Published in final edited form as: Neuroscience. 2013 Oct 1;254:10.1016/j.neuroscience.2013.09.046. doi: 10.1016/j.neuroscience.2013.09.046

Figure 6.

Figure 6

A polyclonal antibody to p75NTR prevented mechanical hyperalgesia induced by NGF and mProNGF. (A) When pre-injected (20 µL) into the paw 4h before NGF (500 ng/10 µl), the antibody prevented any significant hyperalgesia at 0.5h-21h (n=6). (B) A similar inhibition occurred when the antibody was injected 4h before mPro-NGF (500 ng/10 µL) (n=6). Significant elevation of response was found only for the 10g force at 2h after mPro-NGF injection. #P<0.05 vs. baseline-after-antibody values (Wilcoxon matched pairs test, two-tailed), and +P<0.05 vs. baseline-after-antibody values and vs. 21h values for 3 groups comparison: Bsl a.ab., 2h, 21h (Friedman test followed by Dunn's post hoc test). Bsl a.ab. = 2.5h after ab.p75 injection. (C) In controls, where IgG (20 µL) from naïve serum was injected 4h prior to mPro-NGF, hyperalgesia was fully present(n=6; compare with Fig 5). Bsl a.IgG=2.5h after IgG injection.