Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of inhibitors on SK1 or SK2 activity. SK1 activity was measured using 3 μM Sph and 250 μM ATP. SK2 activity was assayed using 10 μM Sph and 250 μM ATP (n = 3 for each compound; results are expressed as % of control ± SD). RB series compounds were used at 50 μM. BML-258 (50 μM) inhibited SK1 activity by 74.5 ± 3.3% (n = 3). The control is 100% and equals activity against Sph alone.
