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Effect of RB-032 on SK1 activity. Concentration-dependent inhibition of SK1 activity by RB-032 using 3 μM Sph and 250 μM ATP. The results are expressed as % of control ± SD; n = 3. The control is 100% and equals activity against Sph alone. RB-032 inhibits SK1 activity with IC50 = 16.9 ± 1.6 μM. RB-005 inhibits SK1 activity with IC50 = 3.6 ± 0.36 μM.7
