Table 2.

Metabolic parameters by weight status and metabolic subtype

Characteristics	Normal Weight (BMI 18.5–24.9 kg/m2)		Overweight (BMI 25–29.9 kg/m2)		Obese (BMI ≥30 kg/m2)
	Metabolically Healthy (n=777)	Metabolically Unhealthy (n=178)	Metabolically Healthy (n=771)	Metabolically Unhealthy (n=752)	Metabolically Healthy (n=425)	Metabolically Unhealthy (n=1471)
Waist circumference (cm)	82.5±9.3	89.4±10.1a	91.9±9.4	97.9±9.1a	103.7±13.6	112.3±12.8a
Elevated waist circumferenceb	4.3	27.5	21.0	65	72.2	96.1
Fasting triglycerides (mg/dl)	103.0±45.9	198.6±88.9a	108.6±49.7	188.5±145.3a	99.6±34.5	168.9±107.3a
Triglycerides ≥150 mg/dl	10.6	70.8	11.3	58.8	4.0	46.9
HDL (mg/dl)	58.5±16.9	42.4±13.1a	55.4±16.0	43.1±13.0a	56.9±14.7	44.7±13.8a
Low HDLc	16.6	74.2	17.9	66.2	11.1	61.3
Fasting glucose (mg/dl)	93.6±24.0	121.5±58.1a	98.6±31.8	118.2±47.9	97.0±33.9	126.4±52.9a
Elevated fasting glucosed	21.2	72.5	23.7	71.9	16.5	82.0
SBP (mmHg)	128.5±19.0	133.8±17.3a	130.0±18.1	134.7±17.8a	130.9±16.3	135.7±18.2a
DBP (mmHg)	74.6±10.5	75.7±9.3	76.5±10.0	76.8±10.3	79.1±10.2	78.9±11.0
Elevated BPe	70.4	94.9	72.4	94.1	73.4	95.0
hsCRP (mg/L)	1.6 (0.7–4.5)	2.7 (1.3–6.9)a	2.1 (0.9–4.5)	2.5 (1.2–5.7)f	3.2 (1.5–6.5)	4.2 (2.0–8.3)a
LDL (mg/dl)	108.3±33.9	107.2±37.0	112.5±35.3	112.1±37.2	114.9±33.6	109.6±35.7f

Data are presented as the mean ± SD, median (interquartile range), or frequency. SBP, systolic BP; DBP, diastolic BP; hsCRP, high-sensitivity C-reactive protein.

^aP<0.001 for difference between metabolic subtypes within individual weight categories.

^bDefined as waist circumference >102 for men or >88 cm for women.

^cDefined as <40 mg/dl for men or <50 mg/dl for women.

^dDefined as fasting glucose ≥100 mg/dl, history of diabetes, or current antidiabetic medication use.

^eDefined as SBP ≥130 mmHg, DBP ≥85 mmHg, and/or current antihypertensive medication use.

^fP<0.05 for difference between metabolic subtypes within individual weight categories.