Table 1.
Baseline characteristics of the patients in the derivation and validation cohorts
| Characteristics | Derivation Cohort (n=698) | Validation Cohort (n=702) | P Value |
|---|---|---|---|
| Age (yr) | 36.1±15.4 | 33.1±14.2 | <0.001 |
| Men (%) | 48.7 | 42.2 | 0.01 |
| Follow-up (yr) | 4.7±1.7–9.3 | 5.1±3.0–8.6 | 0.22 |
| Systolic BP (mmHg) | 125.8±17.7 | 125.9±19.3 | 0.93 |
| Diastolic BP (mmHg) | 74.8±13.2 | 75.2±14.2 | 0.57 |
| Hypertensiona (%) | 25.2 | 26.4 | 0.62 |
| Serum total cholesterol (mg/dl) | 202.9±49.5 | 198.3±45.1 | 0.07 |
| Serum triglycerides (mg/dl) | 127.2±80.4 | 123.2±94.7 | 0.40 |
| Urinary protein excretion levels (%) | |||
| <0.5 g/24 hr | 38.0 | 36.6 | <0.001 |
| 0.5–1.0 g/24 hr | 23.4 | 16.8 | |
| 1.0–3.5 g/24 hr | 31.1 | 34.6 | |
| ≥3.5 g/24 hr | 7.5 | 12.0 | |
| Estimated GFR (%) | |||
| ≥60 ml/min per 1.73 m2 | 72.5 | 74.7 | 0.73 |
| 30–59 ml/min per 1.73 m2 | 22.2 | 20.8 | |
| 15–29 ml/min per 1.73 m2 | 4.3 | 3.4 | |
| <15 ml/min per 1.73 m2 | 1.0 | 1.1 | |
| Pathologic measures (Oxford classification) (%) | |||
| Mesangial hypercellularity score | |||
| M0 (≤0.5 of glomeruli) | 87.8 | 87.8 | 0.99 |
| M1 (>0.5 of glomeruli) | 12.2 | 12.2 | |
| Endocapillary hypercellularity | |||
| E0 (absence) | 64.3 | 58.1 | 0.02 |
| E1 (presence) | 35.7 | 41.9 | |
| Segmental glomerulosclerosis | |||
| S0 (absence) | 29.7 | 20.8 | <0.001 |
| S1 (presence) | 70.3 | 79.2 | |
| Tubular atrophy/interstitial fibrosis | |||
| T0 (≤25%) | 78.9 | 70.7 | <0.001 |
| T1 (26%–50%) | 14.0 | 17.5 | |
| T2 (>50%) | 7.0 | 11.8 |
Values given are means ± SD or percentages.
a
Hypertension was defined as BP≥140/90 mmHg and/or current treatment with antihypertensive agents.