Table 3.
Plasma neutrophil gelatinase-associated lipocalin (pNGAL) performance with predetermined cutoff points
| Times | Sensitivity | Specificity | LR+ | LR− | PPV | NPV |
|---|---|---|---|---|---|---|
| All AKI | ||||||
| Cutoff 100 ng/ml | ||||||
| T0 | 71.0 | 70.4 | 2.4 | 0.4 | 39.0 | 90.6 |
| T6 | 77.4 | 69.6 | 2.5 | 0.3 | 40.0 | 92.2 |
| T12 | 80.2 | 70.9 | 2.8 | 0.3 | 42.3 | 93.1 |
| T24 | 74.8 | 70.6 | 2.6 | 0.3 | 40.4 | 91.3 |
| T48 | 64.4 | 73.3 | 2.4 | 0.4 | 40.4 | 88.1 |
| Cutoff 150 ng/ml | ||||||
| T0 | 53.1 | 86.0 | 3.8 | 0.5 | 50.4 | 87.3 |
| T6 | 54.0 | 86.5 | 4.0 | 0.5 | 51.1 | 87.8 |
| T12 | 54.0 | 88.8 | 4.8 | 0.5 | 56.2 | 87.9 |
| T24 | 56.1 | 86.6 | 4.2 | 0.5 | 52.7 | 88.1 |
| T48 | 48.3 | 92.1 | 6.1 | 0.6 | 63.3 | 86.4 |
| −AKIN≥2a | ||||||
| Cutoff 100 ng/ml | ||||||
| T0 | 93.3 | 64.5 | 2.6 | 0.1 | 11.9 | 99.5 |
| T6 | 96.6 | 62.7 | 2.6 | 0.1 | 11.7 | 99.7 |
| T12 | 96.6 | 63.1 | 2.6 | 0.1 | 11.7 | 99.7 |
| T24 | 92.9 | 63.8 | 2.6 | 0.1 | 11.4 | 99.4 |
| T48 | 84.6 | 67.5 | 2.6 | 0.2 | 11.7 | 98.9 |
| Cutoff 150 ng/ml | ||||||
| T0 | 80.0 | 80.7 | 4.2 | 0.2 | 17.5 | 98.7 |
| T6 | 72.4 | 80.7 | 3.8 | 0.3 | 16.0 | 98.3 |
| T12 | 79.3 | 82.9 | 4.6 | 0.3 | 19.0 | 98.8 |
| T24 | 78.6 | 80.5 | 4.0 | 0.3 | 16.8 | 98.7 |
| T48 | 69.2 | 85.9 | 4.9 | 0.4 | 20.0 | 98.2 |
LR, likelihood ratio; PPV, positive predictive value; NPV, negative predictive value; T, study times; AKIN, Acute Kidney Injury Network classification.
a
−AKIN≥2, analysis of pNGAL in patients classified as AKIN≥2.