Table 2.
Association of HIV/HCV group with concurrently elevated (>75th percentile) inflammatory biomarkers
|
Model A (N = 218) |
Unadjusted |
Adjusteda |
||
|---|---|---|---|---|
| |
POR (95% CI) |
p-value |
POR (95% CI) |
p-value |
| Undetectable | 1 | -- | 1 | -- |
| HIV mono-detectable |
1.89 (1.03, 3.46) |
0.04 |
1.52 (0.68, 3.41) |
0.31 |
| HCV mono-detectable |
2.70 (1.29, 5.68) |
<0.01 |
2.95 (1.08, 8.01) |
0.03 |
| HIV/HCV detectable |
3.48 (1.87, 6.46) |
<0.01 |
2.49 (1.05, 5.89) |
0.04 |
| FIB-4 ≥ 1.45 |
-- |
-- |
2.56 (1.39, 4.35) |
<0.01 |
| High cholesterol |
-- |
-- |
1.74 (0.97, 3.14) |
0.06 |
| Age greater than median (42 yrs) |
-- |
-- |
0.61 (0.36, 1.04) |
0.07 |
| BMI ≥ 30 kg/m2 |
-- |
-- |
1.81 (0.93, 3.54) |
0.08 |
| Ever smoker |
-- |
-- |
1.53 (0.85, 2.78) |
0.16 |
| CD4 > 200 cells/mm3 |
-- |
-- |
0.63 (0.31, 1.26) |
0.19 |
| Renal disease |
-- |
-- |
2.15 (0.67, 6.86) |
0.20 |
| Diabetes |
-- |
-- |
1.90 (0.58, 6.21) |
0.29 |
| Current antiretroviral therapy use |
-- |
-- |
0.74 (0.42, 1.31) |
0.30 |
| Prevalent cardiovascular disease |
-- |
-- |
1.82 (0.56, 5.97) |
0.32 |
| Hypertension |
-- |
-- |
0.78 (0.42, 1.45) |
0.44 |
| At-risk alcohol consumption |
-- |
-- |
0.94 (0.55, 1.62) |
0.83 |
| Female | -- | -- | 1.03 (0.55, 1.94) | 0.93 |
aModel adjusted for age, gender, FIB-4 score, at-risk drinking, CD4 count, ART use, and self-reported comorbidity.
The ordinal logistic regression model estimates the proportional odds of having more than N concurrently elevated biomarkers versus N or fewer where N = 0, 1, 2, or 3 or more.
POR proportional odds ratio, HIV human immunodeficiency virus, HCV hepatitis C virus, FIB 4-liver fibrosis index-4, BMI body mass index, CD4-CD4+ T-lymphocyte count.