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Transmission electron microscopy analysis of T. cruzi epimastigotes treated with NQ9. (A-C) This naphthoquinone (2.6 μM) induced morphological alterations in the mitochondrion, including swelling (*) and the formation of membranous structures (black arrows) inside the organelle. Parasites treated with NQ9 also presented atypical cytosolic membranous structures (white arrowheads) and intense cytosolic vacuolization (V). Bars = 500 nm.
