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IC50 values (μM) of the naphthoquinones on intracellular amastigotes of T. cruzi
| Cpd | HMC | Macrophages |
|---|---|---|
| NQ1 |
2.81 ± 0.43a,b |
3.65 ± 0.71 |
| NQ8 |
1.53 ± 0.11 |
1.49 ± 0.01 |
| NQ9 |
2.48 ± 0.39 |
1.63 ± 0.18 |
| NQ12 | 9.83 ± 2.64 | 2.51 ± 0.71 |
aThe IC50 was calculated for the endocytic index (number of parasites/100 host cells) after two days of treatment.
bMean ± standard deviation of at least three independent experiments.
