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The phenotype and genotypes of β-thalassemia
| Phenotypes | Genotype | MCV | Anemia | Hb electrophoresis |
|---|---|---|---|---|
| Silent carrier |
ββ+ |
Low/Normal |
None |
Normal |
| Minor (Trait) |
ββ° |
Low |
Mild |
High Hb A2 |
| Intermedia |
β+β+ and others |
Low |
Moderate |
Presence of small amount of A and could be similar to Major |
| Major | β°β° | Low | Severe | Hb A absent, only Hb A2 and Hb F are present |
HB hemoglobin, Hb A adult hemoglobin, Hb F fetal hemoglobin, MCV mean corpuscular volume.
