Table 3.
Any osteoporotic fracture outcomes according to baseline characteristics and treatment group
| Baseline characteristic |
B-Vitamins |
Placebo |
p-value |
P-value for interaction | |
|---|---|---|---|---|---|
|
(n = 4089) |
(n = 4075) |
(log-rank test) |
|||
| N (%) | N (%) | ||||
| Sex |
Male |
27 (1.0) |
28 (1.1) |
0.90 |
0.50 |
| |
Female |
40 (2.7) |
50 (3.4) |
0.21 |
|
| Age |
<65 yrs |
12 (0.6) |
11 (0.5) |
0.90 |
0.57 |
| |
> = 65 yrs |
55 (2.8) |
67 (3.5) |
0.28 |
|
| Ethnicity |
Western European |
48 (2.9) |
57(3.5) |
0.35 |
0.65 |
| |
Oriental |
9 (0.9) |
6 (0.6) |
0.42 |
|
| |
South Asian |
4 (0.4) |
3 (0.3) |
0.74 |
|
| |
Other |
1 (0.4) |
5 (1.7) |
0.12 |
|
| Oxford Handicap Score |
> = 3 |
14 (1.5) |
21 (2.2) |
0.18 |
0.34 |
| |
<3 |
51 (1.7) |
56 (1.9) |
0.63 |
|
| Smoking (ever) |
Yes |
36 (1.8) |
36 (1.8) |
0.96 |
0.30 |
| |
No |
31 (1.5) |
42 (2.1) |
0.16 |
|
| Alcohol (any) |
Yes |
26 (2.2) |
28 (2.5) |
0.71 |
0.76 |
| |
No |
41 (1.4) |
50 (1.7) |
0.32 |
|
| Diabetes |
Yes |
9 (0.9) |
15 (1.6) |
0.21 |
0.34 |
| |
No |
58 (1.9) |
63 (2.0) |
0.62 |
|
| Stroke |
Yes |
13 (2.1) |
15 (2.3) |
0.75 |
0.94 |
| |
No |
54 (1.6) |
63 (1.9) |
0.38 |
|
| Myocardial infarction |
Yes |
8 (2.7) |
7 (2.3) |
0.71 |
0.49 |
| |
No |
59 (1.6) |
71 (1.9) |
0.25 |
|
| Hypertension |
Yes |
48 (1.7) |
57 (2.0) |
0.40 |
0.98 |
| |
No |
19 (1.6) |
21 (1.8) |
0.64 |
|
| Depression |
Yes |
8 (2.9) |
8 (3.0) |
0.83 |
0.51 |
| |
No |
35 (1.0) |
49 (1.5) |
0.14 |
|
| Antidepressant medication |
Yes |
11 (4.0) |
13 (4.6) |
0.67 |
0.99 |
| |
No |
56 (1.5) |
65 (1.8) |
0.37 |
|
| Corticosteroid medication |
Yes |
10 (3.3) |
13 (4.7) |
0.05 |
0.98 |
| |
No |
57 (1.5) |
65 (1.7) |
0.46 |
|
| Osteoporosis Medication |
Yes |
4 (1.3) |
5 (1.8) |
0.37 |
0.62 |
| |
No |
30 (0.8) |
31 (0.8) |
0.44 |
|
| Homocysteine |
< median |
10 (3.2) |
10 (3.5) |
0.77 |
0.81 |
| (median 12.6 micromol/L) |
(n = 595) |
||||
| > = median |
8 (2.7) | 12 (3.8) | 0.53 | ||
| (n = 610) |