Table 2.
Mortality results following experimental challenges with 4 RHDV2 or 1 RHDV reference strains.
| Study | Rabbit origin | Administration route | Inoculum strain | Mortality | Seropositivity of the survivors (doubtful)2 | Mortality 2nd challenge RHDV BS89 |
|---|---|---|---|---|---|---|
|
A1 |
NZ |
IM |
10-07 |
1/5 |
/ |
|
| |
V/RHD/4 |
3/5 |
/ |
|
||
|
B1 |
NZ |
oral |
10-28 |
6/8 |
/ |
|
|
C |
NZ |
IM |
10-28 |
1/2 |
1/1 |
|
| |
oral |
10-28 |
2/2 |
/ |
|
|
|
D |
NZ |
oral |
10-28 |
3/9 |
6/6 |
|
|
E |
NZ |
oral |
10-28 |
0/5 |
5/5 |
|
|
F |
NZ |
oral |
Ud11 |
1/5 |
4/4 |
0/43 |
|
G1 |
NZ |
oral |
10-32 |
0/8 |
/ |
|
| |
V/RHD/4 |
8/8 |
/ |
|
||
|
H |
NZ |
oral |
10-32 |
0/3 |
3/3 |
|
|
I |
NZ |
IV |
10-32 |
0/4 |
4/4 |
0/13 |
| |
oral |
10-32 |
1/6 |
5/5 |
2/43 |
|
|
J |
NZ |
oral |
10-32 |
2/5 |
3/3 |
|
|
K |
NZ |
oral |
10-32 |
0/5 |
4(1)/5 |
|
|
L |
NZ |
oral |
10-32 |
0/5 |
5/5 |
0/43 |
| Rural | oral | 10-32 | 0/5 | 5/5 | 1/5 |
The experimental challenges were performed with RHDV2 strains 10–07, 10–28, 10–32, and Ud11, or with the French RHDV reference strain V/RHD/4, using different inoculation routes. For experiments F, I, and L, mortality results following a second challenge with the Italian RHDV reference strain BS89 of the survivor rabbits are shown.
NZ New Zealand, IM intramuscularly route, IV intravenous route.
1no serological data.
2doubtful because just above the threshold.
3the 2nd challenge was performed on a part of the survivor rabbits.