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. 2013 Sep 18;10:114. doi: 10.1186/1742-2094-10-114

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Copyright © 2013 Kohman et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Proportion of hippocampal microglia positive for MHC II and CD86, Experiment 2. (A) Percentage of hippocampal microglia isolated from running-wheel (n=7) and control (n=7) aged females from Experiment 2 that were positive for MHC II. Wheel-running significantly decreased the proportion of MHC II positive microglia in the hippocampus. (B) Percentage of hippocampal microglia isolated from running-wheel and control aged females that were positive for CD86. The proportion of CD86 positive microglia was significantly reduced by running-wheel access. Means ± SEM. * indicates a significant difference from control mice.