Table 5.
Prevalence of symptoms and tumor markers as related to tumor malignancy and stage
|
Malignant |
Benign |
OR (95% CI) |
||||||
|---|---|---|---|---|---|---|---|---|
|
Stage I |
Stage II-IV |
All |
(n = 116) |
All malignant |
Stage I |
Stage II-IV |
Stage II-IV |
|
| (n = 32) | (n = 28) | (n = 60) | vs. benign | vs. benign | vs. benign | vs. stage I | ||
| Cluster |
% |
% |
% |
% |
|
|
|
|
| Abdomen |
72 |
64 |
68 |
31 |
4.7 (2.4 to 9.4) |
5.7 (2.4 to 13.5) |
4.0 (1.7 to 9.5) |
0.7 (0.2 to 2.1) |
| Pain |
44 |
68 |
55 |
22 |
4.2 (2.1 to 8.2) |
2.7 (1.6 to 6.1) |
7.3 (2.9 to 18.1) |
2.7 (0.9 to 7.8) |
| Eating |
37 |
54 |
45 |
12 |
6.0 (2.8 to 12.7) |
4.4 (1.8 to 10.8) |
8.4 (3.3 to 21.3) |
1.9 (0.7 to 5.4) |
| Symptom index (SI) |
78 |
79 |
78 |
40 |
5.5 (2.7 to 11.3) |
5.4 (2.2 to 13.6) |
5.6 (2.1 to 14.8) |
1.0 (0.3 to 3.5) |
| CA125 |
47 |
85 |
65 |
24 |
5.7 (2.8 to 12.2) |
3.5 (1.5 to 9.2) |
18.4 (5.4 to 79.4) |
5.1 (1.3 to 25.1) |
| HE4 |
34 |
86 |
58 |
15 |
7.6 (3.7 to 15.6) |
2.8 (1.2 to 6.9) |
32.7 (10.1 to 105.4) |
11.4 (3.2 to 41.4) |
| ROMA PI | 34 | 82 | 57 | 12 | 9.5 (4.4 to 20.3) | 3.8 (1.5 to 9.6) | 33.5 (11.0 to 102.4) | 8.7 (2.6 to 29.5) |
Symptom index (SI) = presence of at least one of the symptoms included in the clusters abdomen, pain and/or eating.
Cutoff points in premenopausal women: CA125 = 69.8 U/ml, HE4 = 41.6 pMol/L, ROMA predictive index (PI) = > 5.01%. In postmenopausal women: CA125 = 21.7 U/L, HE4 = 96.6 pMol/L, ROMA-PI > 18.2%. PPV positive predictive value, NPV negative predictive value.