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. 2001 Nov 21;70(1):181–191. doi: 10.1086/338308

Table 11.

Estimated Sample Sizes for Four Affected Siblings under Single-Locus Models[Note]

Estimated Sample Size
Dominant Model
 Additive Model
 Recessive Model
Pedigree and Statistic(s) 1 2 3 4 5 6 7 8 9 10 11 12
Four males:
 Optimal test 10 10 10 17 10 10 10 17 10 10 10 17
 Sall 10
 10
 10
 17
 10
 10
 10
 17
 10
 10
 10
 17
 SApairs, SX50, SGHpairs, SX75 11 11 11 18 11 11 11 18 11 11 11 18
Three males–one female:
 Optimal test 11 11 11 19 11 11 11 20 10 11 11 23
 Sall 11
 11
 12 19
 11
 11
 12 20
 10
 11
 11
 26
 SApairs 12 12 13 20 12 12 13 21 11 12 12 29
 SX50, SGHpairs 12 12 13 20 12 12 13 21 12 12 13 24
 SX75 12 12 12 20 12 12 12 21 11 12 12 26
Two males–two females:
 Optimal test 14 14 14 25 15 15 16 29 10 10 10 23
 Sall 14
 15 15
 25
 15
 15
 16 29 10
 11 11 24
 SApairs 16 16 16 26 17 17 17 32 11 11 11 25
 SX50 15 15 16 26 16 16 16 30 12 12 12 25
 SGHpairs 16 16 16 27 16 16 17 29 12 13 13 26
 SX75 15 16 16 26 16 16 17 30 11 11 12 25
One male–three females:
 Optimal test 22 24 25 53 32 33 34 65 10 10 10 19
 Sall 25 26 27
 55 32
 33
 34
 66 11 11 11 20
 SApairs, SX50 25 26 28 55 35 36 37 70 11 11 11 20
 SGHpairs 28 29 30 60 33 34 35 66 12 12 12 22
 SX75 26 27 29 57 33 34 35 66 11 11 12 21
Four females:
 Optimal test 334 337 340 404 280 282 284 347 10 10 10 18
 Sall 358
 360
 362
 412
 282
 284
 286
 348
 10
 10
 11
 18
 SApairs, SX50, SGHpairs, SX75 384 385 386 429 291 292 293 349 11 11 11 19

Note.— Notation is as described in the footnotes to table 9.