Figure 5.

Likelihood of the age of the β^S mutation, (estimated according to the DMLE method, under the assumption that 45 β^S chromosomes show the same associated 5′ cluster RFLP haplotype despite a recombination rate of 1.6 × 10⁻³ per generation (Chakravarti et al. 1984). The present population is assumed to be either (A) 10,000 or (B) 1 million individuals. Likelihoods are plotted for total exponential growth rates (see text) ranging from 0% per generation (extreme right line) to the largest one that permits retention of at least one β^S chromosome in the population in the whole CI (see DMLE subsection) (extreme left line) by increments of 1%. The DMLE method gives an ML value of one generation. An upper limit for the age of the β^S mutation is found when the log-likelihood of that age is three units less than the maximum.