Table 4.

ML Estimates of the Age of the β^S Mutation in the Mandenka Population

Statistical Analysis andDemographic Model	Initial Frequencyof Neutral AlleleAssociated with βS	Age of βS(generations)	95% CI
BDMC:
DNA sequences:
N= 10,000	…	10	0–1200
N= 1,000,000	…	55	15–600
DMLE:
5′ Cluster RFLPs:
N = 10,000	…	0	0–140
N= 1,000,000	…	0	0–100
Simulations:
5′ Cluster RFLPs:
Stationary population:
N= 1,000	.18	55	25–735
N= 5,000	.18	60	35–205
N= 10,000	.20	60	40–145
Logistic growth:
N0 = 1,000, K = 10,000:
r = .001	.18	50	25–590
r = .01	.20	50	25–210
r = .02	.18	45	25–160
N0 = 100, K= 10,000:
r = .001	.22	20	5–725
r = .01	.14	30	5–400
r = .02	.18	30	5–250
DNA sequences:
Stationary population:
N= 1,000	.010	65	25–(>1,000)
N= 5,000	.020	65	35–(>1,000)
N= 10,000	.004	70	45–690
Logistic growth:
N0 = 1,000, K = 10,000:
r = .001	.006	60	25–(>1,000)
r = .01	.004	60	25–660
r = .02	.010	60	25–585
N0 = 100, K= 10,000:
r = .001	.008	35	5–(>1,000)
r = .01	.002	165	5–890
r = .02	.004	95	5–660