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. Author manuscript; available in PMC: 2013 Dec 3.
Published in final edited form as: Behav Brain Res. 2012 Jan 8;229(1):160–167. doi: 10.1016/j.bbr.2012.01.001

FIGURE 3. Anti-allodynic action of morphine and diazepam in rats developing chronic inflammatory pain.

FIGURE 3

Changes in withdrawal threshold to mechanical stimulation with the dynamic von Frey filament were assessed on day 28 on both (A) ipsilateral and (B) contralateral hind paws of CFA animals after acute s.c. injections of saline 9%, morphine (3 mg/kg, ms) or diazepam (1 mg/kg, dzp). Morphine and diazepam were respectively injected 30 min and 60 min before testing. All data represent means ± S.E.M. (CFA-treated rats receiving morphine or diazepam, n = 5–6; and saline, n = 11). Statistical analyses were performed using a one-way ANOVA followed by a Dunnett’s multiple comparison test. The asterisks denote significant differences from saline-injected animals; ***P < 0.001 and **P < 0.01.