Table 2.
Top genes correlated with ERBB2 and ESR1 and their minimum, two-sided P interaction values for trastuzumab when examined as a categorical variable (quartiles)
| Gene symbol | Correlation with ERBB2 | Minimum P intercation |
|---|---|---|
| ERBB2* | 1 | .03 |
| GRB7* | 0.912 | .06 |
| C17orf37* | 0.833 | .0003 |
| KRT7 | 0.498 | .047 |
| TMEM45B | 0.453 | .29 |
| ORMDL3 | 0.448 | .08 |
| C1orf93 | 0.427 | .10 |
| SPDEF | 0.4 | .01 |
| VEGFA | 0.395 | .24 |
| FGFR4 | 0.347 | .35 |
| Correlation with ESR1 | ||
| ESR1* | 1 | .06 |
| TBC1D9 | 0.757 | .49 |
| CA12* | 0.733 | .002 |
| IGF1R* | 0.731 | .04 |
| GATA3* | 0.727 | .004 |
| THSD4 | 0.727 | .12 |
| NAT1* | 0.701 | .08 |
| SLC39A6 | 0.685 | .21 |
| SCUBE2 | 0.637 | .47 |
| SIAH2 | 0.632 | .19 |
* Genes selected for prediction model.