Table 1.
Antiviral and cytotoxic activity of test compounds in cell culture
| EC50a/µM | |||||
|---|---|---|---|---|---|
| Virus | 1a | 1b | 1c | Ribavirin | |
| HEL cells | |||||
| HSV-1 (KOS) | >4 | >100 | >100 | >250 | |
| HSV-1 TK− | >4 | >100 | >100 | >250 | |
| HSV-2 (G) | >4 | >100 | >100 | >250 | |
| VV | >4 | >100 | >100 | >250 | |
| VSV | >4 | >100 | >100 | 146 | |
| HCMV (AD-169 & Davis) | 1.8–2.0 | — | >20 | — | |
| VZV (OKA & 07/1) | 1.6–1.7 | — | 47–56 | — | |
| HeLa cells | |||||
| VSV | 4 | >100 | >100 | 29 | |
| Coxsackie virus B4 | >4 | >100 | >100 | 146 | |
| RSV | >4 | >100 | >100 | 10 | |
| CEM cells | |||||
| HIV-1(IIIB) HIV-2(ROD) | >2 | >100 | >50 | >50 | |
| Vero cells | |||||
| Parainfluenza-3 virus | >4 | >100 | >100 | 85 | |
| Reovirus-1 | >4 | 100 | >100 | >250 | |
| Sindbis virus | >4 | 100 | >100 | >250 | |
| Coxsackie virus B4 | >4 | >100 | >100 | >250 | |
| Punta Toro virus | >4 | 20 | >100 | 126 | |
| MDCK cells | |||||
| Influenza virus (AH3N2) | >0.8 | — | >20 | 9 | |
| Influenza virus A (H1N1) | >0.8 | — | >20 | 9 | |
| Influenza virus B | >0.8 | — | >20 | 9 | |
| Cell line | MCCb/µM | ||||
| HEL | ≥4 | >100 | ≥100 | >250 | |
| HeLa | 20 | >100 | >100 | >250 | |
| Vero | 20 | >100 | >100 | >250 | |
| MDCK | 4 | — | 100 | >100 | |
a
50% Effective concentration, or compound concentration required to inhibit virus-induced cytopathicity by 50%.
b
Minimal cytotoxic concentration, or compound concentration required to cause a microscopically visible alteration of cell morphology.