Figure 6.
Metabolite signal time-courses from heart ROI after bolus injections of hyperpolarized [2-13C]pyruvate with alternate acquisition of (A) the glutamate frequency band and the [2-13C]pyruvate band or (B) the glutamate band and the [2-13C]lactate band. The glutamate, acetylcarnitine and [1-13C]pyruvate signals are from the glutamate band acquisition. The SNR of acetoacetate was insufficient to plot time-courses. The 13C1-pyruvate signal is from the 13C1-13C2 doublet from natural abundance [1,2-13C]pyruvate in the injected [2-13C]pyruvate solution.