Fig. 1.

Absolute whole lung weights in Npc1^+/+ and Npc1^−/− mice over the age range of 8 to 80 days, and weights of individual lung lobes in Npc1^+/+ and Npc1^−/− mice at 57–60 days. The data for lung weights from all the present experiments were pooled with those from previous projects in this laboratory using Npc1 mice. Except for the 8-day time point, the data are grouped for animals over successive spans of 3 days each (A). Lung weights were obtained from a total of 188 mice (94 for each genotype). The numbers of mice at each age varied considerably. At the 8, 19–22, 27–30, 48–51, 52–55, and 68–71 day time points there was a minimum of 9 mice of each genotype. For all other points there was a minimum of 4 mice of each genotype except in the group at 61–64 days where there were just two Npc1^+/+ mice. Separate groups of mice in the age range of 57–60 days were used for the measurement of the weights of individual lobes (B). These data are from 4 mice of each genotype. All values represent the mean ± 1 SEM. The asterisk denotes that the value for the Npc1^−/− mice is significantly different from that for the Npc1^+/+ controls at that particular age (p<0.05).