Table 1.
PK parameter | Component | Liposome | Solution (USP) |
---|---|---|---|
AUC0–6h (mg·h/L) | PB1 | 4.77 | 2.76 |
PB2 | 1.07 | 0.30 | |
PB3 | 0.39 | 0.33 | |
ile-PB1 | 0.64 | 0.64 | |
T1/2 (h) | PB1 | 0.60 | 0.32 |
PB2 | 0.44 | 0.21 | |
PB3 | 0.30 | 0.28 | |
ile-PB1 | 0.42 | 0.29 | |
CL (mL/h/kg) | PB1 | 444.10 | 790.06 |
PB2 | 308.28 | 899.90 | |
PB3 | 489.78 | 664.39 | |
ile-PB1 | 562.65 | 575.61 | |
Vss (ml/kg) | PB1 | 382.90 | 373.06 |
PB2 | 197.77 | 274.74 | |
PB3 | 209.87 | 267.30 | |
ilePB1 | 338.41 | 241.10 |
USP, US Pharmacopeia; AUC0–6h, area under the concentration–time curve from 0–6 h; T1/2, elimination half-life; CL, clearance; Vss, volume of distribution at steady state.