Table 3.

Uncontrolled trials of selective serotonin reductase inhibitors in pseudobulbar affect

Drug	Disease	Number of subjects	Main findings	Reference
Fluoxetine	MS or stroke	13	Reduced episode rate	30
Fluoxetine	TBI or stroke	6	Reduced severity on unvalidated scale	31
Fluvoxamine	ALS, MS, or stroke	10	Reduced episode rate	32
Paroxetine, citalopram	TBI	26	Reduced severity on unvalidated scale	6

Abbreviations: ALS, amyotrophic lateral sclerosis; MS, multiple sclerosis; TBI, traumatic brain injury.