Table 2. Significance levels (P<0.05) for production and release of inflammatory mediators from MCP-1^−/− mouse hepatocytes cultured under normoxic or hypoxic conditions (1–72 h) as determined by one-way ANOVA.

	Normoxia		Hypoxiaa
	Lysate	Supernatant	Lysate	Supernatant
GM-CSF	0.918	0.535	0.239	0.423
IFN-γ	0.897	0.371	<0.001	0.530
IL-1α	0.869	0.249	0.002	0.034
IL-1β	0.748	0.031	0.008	0.369
IL-2	0.978	0.332	0.006	0.282
IL-4	0.982	0.669	0.978	0.054
IL-5	0.757	1.0	0.379	1.0
IL-6	<0.001	0.475	<0.001	0.403
IL-10	0.439	0.696	<0.001	0.570
IL-13	0.191	0.888	<0.001	0.978
IL-17	0.992	0.995	0.960	0.945
IP-10	0.783	0.572	0.925	0.518
KC	<0.001	<0.001	0.234	0.009
MCP-1	0.823	0.535	0.573	0.782
MIG	0.003	0.761	0.609	0.068
MIP-1α	0.363	0.078	0.009	0.653
TNF-α	0.833	1.0	0.002	1.0
VEGF	0.599	<0.001	0.242	0.019

^aFor hypoxia time courses, the analysis was performed using as baseline the respective concentration values for normoxia at 1 h.