Table 1.
Px |
Age, year |
Symptom onset |
Sample collected |
Laboratory confirmedd |
Thin/thick blood smears |
PCR result |
Pfcrt haplotypef |
||
---|---|---|---|---|---|---|---|---|---|
Parasitaemia | Parasite densitye | Gametocytes | |||||||
1a |
37 |
10/23/2010 |
10/27/2010 |
11/08/2010 |
(+) |
UA |
UA |
(+) |
CVIETg |
2 |
28 |
10/30/2010 |
11/03/2010 |
11/04/2010 |
(+) |
71,408 |
(−) |
(+) |
CVMNK |
3 |
22 |
10/13/2010 |
11/09/2010 |
11/09/2010 |
(+) |
6,008 |
(−) |
(+) |
CVMNK |
4b,c |
44 |
11/07/2010 |
11/09/2010 |
11/10/2010 |
(+) |
18,200 |
(−) |
(+) |
CVMNK |
5 |
22 |
10/12/2010 |
11/09/2010 |
11/12/2010 |
(+) |
2,152 |
(−) |
(+) |
CVMNK |
6 |
48 |
AI |
11/09/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
7 |
25 |
AI |
11/09/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
8 |
30 |
AI |
11/09/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
9 |
22 |
AI |
11/09/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
10 |
28 |
AI |
11/12/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
11 |
26 |
AI |
11/09/2010 |
11/29/2010 |
(−) |
na |
na |
(+) |
CVMNK |
12 | 25 | AI | 11/09/2010 | 11/29/2010 | (−) | na | na | (+) | CVMNK |
Px: patient; na: not applicable; AI: asymptomatic infection; UA: data unavailable.
aParasite density cannot be calculated; PCR results were obtained from post-mortem tissue.
bPatient was initially diagnosed with P. falciparum by the OptiMAL-IT Rapid test.
cPatient reported a previous malaria infection in the DRC; received artequine as treatment.
dDates corresponds to thin/thick blood smears results for patient 1–5 and PCR results for patients 6-12.
eNo of asexual parasites/μl of blood.
fCQ resistance type in the pfcrt gene: CVMNK (wild type); CVIET (CQ resistant).
gSequencing results showed a major peak for CVIET and minor peak for CVMNK when retested.