EEG trace and NIRS recordings during seizure 1 of Subject 1. The time zero is the start of the seizure as defined by clinical inspection of the EEG trace (performed by SC). rHbO: relative oxyhemoglobin, rHbR: relative deoxyhemoglobin, rtHb: relative total hemoglobin, rCMRO2: relative cerebral metabolic rate of oxygen, rCBF: relative cerebral blood flow. (F: frontal, T: temporal, C: central, P: parietal, O: occipital, EKG: electrocardiogram). The blue box indicates the start and the end of the epileptic seizure determined from electrophysiology as well as patient video recordings by an epileptologist.