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. 2013 Sep 26;9:186. doi: 10.1186/1746-6148-9-186

Table 3.

The potential diagnostic biomarkers of any two groups of CK, SK, and NC

No Compoundsa CK vs NC
 SK vs NC
 CK vs SK
LR+b AUCc LR+b AUCc LR+b AUCc
1
 GA
 0.25
 0.122
 0.38
 0.176
  
  
2
 L-ala
 0.06
 0.149
  
  
 0.30
 0.216
3
 L-ser
  
  
  
  
 0.36
 0.240
4
 GLCA
 0.19
 0.153
 0.05
 0.19
  
  
5
 Erythritol
 0.28
 0.161
  
  
  
  
6
 Ribitol
 0.26
 0.171
  
  
  
  
7
 Glc
 0.24
 0.176
 1.07
 0.259
  
  
8
 LA
 0.07
 0.178
 0.18
 0.199
  
  
9
 Gal
 0.34
 0.184
 0.42
 0.22
  
  
10
 GABA
 0.15
 0.221
  
  
 0.26
 0.261
11
 DHB
  
  
  
  
 0.36
 0.257
12
 THB
 0.38
 0.231
  
  
  
  
13
 pGlu
 0.47
 0.269
  
  
  
  
14
 MMA
  
  
 1.01
 0.283
  
  
15
 Melibiose
 1.05
 0.277
  
  
  
  
16
 Citrate
  
  
  
  
 0.42
 0.281
17
 3HV
  
  
 2.32
 0.79
  
  
18
 AABA
  
  
 11.80
 0.79
  
  
19
 L-leu
 1.89
 0.638
  
  
  
  
20
 Xylitol
 3.16
 0.752
  
  
  
  
21
 Gly
 2.33
 0.76
 7.90
 0.837
  
  
22
 2Me3HB
 3.60
 0.764
  
  
  
  
23
 AMA
 2.57
 0.773
 3.09
 0.822
  
  
24
 AABA
 1.05
 0.773
  
  
  
  
25
 αTP
 2.37
 0.783
  
  
  
  
26
 L-ile
 3.16
 0.814
 3.32
 0.827
  
  
27
 HMG
 4.07
 0.848
  
  
  
  
28
 Sitosterol
 3.00
 0.88
  
  
 1.91
 0.741
29
 PA
 6.35
 0.897
 5.29
 0.838
  
  
30
 C-9-HA
 3.81
 0.909
 2.75
 0.842
  
  
31
 Hep
 7.02
 0.911
 5.15
 0.866
  
  
32
 MA
 6.01
 0.913
 3.21
 0.845
  
  
33
 SA
 6.35
 0.913
 3.44
 0.842
  
  
34
 2PC
 4.97
 0.918
 7.78
 0.923
  
  
35
 T-9-OA
 4.21
 0.924
 3.58
 0.868
  
  
36
 3HV
 9.09
 0.95
  
  
 2.38
 0.764
37 BHBA 10.22 0.977 8.13 0.965 5.11 0.953

aAbbreviations of compounds’ name are same as Table  2.

b+LR, positive likelihood ratio.

cAUC, area under the curve. If AUC value is more than 7.00 or less than 0.30, compound is considered to be a potential diagnostic biomarker of disease.