Table 4.
Hazard ratios for all-cause mortality by ESA and Hb category
| |
|
|
|
All-cause mortality |
|
|---|---|---|---|---|---|
| ESA (units/week) | Hb (g/dL) | Patients (n) | Unadjusted HR | Adjusted HR1 | Adjusted HR2 |
| • HD patients |
|
|
|
|
|
| ≤8,000 |
≥11 |
380 |
1 |
1 |
1 |
| ≤8,000 |
<11 |
264 |
1.29 (1.01-1.65) |
1.33 (1.04-1.70) |
1.18 (0.91-1.52) |
| >8,000 |
≥11 |
158 |
1.35 (1.01-1.80) |
1.52 (1.13-2.04) |
1.28 (0.94-1.73) |
| >8,000 |
<11 |
211 |
1.72 (1.34-2.20) |
1.91 (1.48-2.47) |
1.37 (1.04-1.80) |
| • PD patients |
|
|
|
|
|
| ≤4,000 |
≥11 |
204 |
1 |
1 |
1 |
| ≤4,000 |
<11 |
91 |
1.59 (0.96-2.63) |
1.94 (1.15-3.27) |
1.56 (0.91-2.68) |
| >4,000 |
≥11 |
113 |
2.55 (1.66-3.92) |
1.89 (1.20-2.97) |
1.56 (0.96-2.51) |
| >4,000 | <11 | 53 | 2.34 (1.34-4.10) | 3.18 (1.74-5.79) | 2.41 (1.27-4.57) |
Values are shown as hazard ratios (95% CI).
Categories are defined by a combination of ESA dose (below or from median) and Hb level (≥11 and <11 g/dL). The category with the high ESA dose and Hb <11 corresponds to ESA resistant patients and the category with the low ESA dose and Hb ≥11 corresponds to good ESA responders.
1 Adjusted for age, sex, weight, primary kidney disease, diabetes mellitus, malignancy, cardiovascular disease.
2 Additional adjusted for weekly Kt/V urea, rGFR, nutritional status, albumin, ferritin, PTH and CRP.