Table 5.
Hazard ratios for all-cause mortality by ERI quartile
| |
|
|
|
All-cause mortality |
|
|---|---|---|---|---|---|
| ERI ESA/kg/Hb | ERI quartile | Patients (n) | Unadjusted HR | Adjusted HR1 | Adjusted HR2 |
| • HD patients |
|
|
|
|
|
| <5.87 |
1 |
253 |
1 |
1 |
1 |
| 5.87-9.46 |
2 |
253 |
1.08 (0.82-1.43) |
1.16 (0.88-1.55) |
1.11 (0.83-1.49) |
| 9.47-14.28 |
3 |
254 |
1.33 (1.01-1.74) |
1.28 (0.97-1.68) |
1.07 (0.81-1.43) |
| >14.28 |
4 |
253 |
1.81 (1.39-2.36) |
1.85 (1.41-2.42) |
1.34 (1.00-1.80) |
| • PD patients |
|
|
|
|
|
| <3.21 |
1 |
115 |
1 |
1 |
1 |
| 3.21-4.81 |
2 |
115 |
0.63 (0.36-1.12) |
0.45 (0.25-0.80) |
0.45 (0.25-0.83) |
| 4.82-7.90 |
3 |
115 |
1.24 (0.75-2.03) |
0.95 (0.56-1.61) |
0.77 (0.43-1.36) |
| >7.90 | 4 | 116 | 1.72 (1.07-2.77) | 1.46 (0.88-2.41) | 1.18 (0.68-2.07) |
Values are shown as hazard ratios (95% CI).
Categories are defined by quartiles of ERI (weekly ESA dose/kg/Hb). The highest ERI quartile (quartile 4) corresponds to ESA resistant patients and the lowest ERI quartile (quartile 1) corresponds to good ESA responders.
1 Adjusted for age, sex, weight, primary kidney disease, diabetes mellitus, malignancy, cardiovascular disease.
2 Additional adjusted for weekly Kt/V urea, rGFR, nutritional status, albumin, ferritin, PTH and CRP.