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. 2002 Jan 3;70(2):547–555. doi: 10.1086/338921

Figure 1.

Figure 1

Haplotype analysis in the two families. A, Relative positions of the 12 polymorphic markers used, with their approximate distances from the tip of the short arm of chromosome 2. D2S294, D2S333, D2S335, D2S326, D2S364, D2S1391, D2S389, and D2S117 are microsatellite repeats spanning a 20.7-cM interval in the vicinity of the HOXD cluster on chromosome 2q31 (Sheffield et al. 1995; Dib et al. 1996). HOXD10, originally reported as HOX4E (Rosen and Brown 1993), lies in the 3′ UTR of HOXD10. HOXD11 (a TG repeat in the intron of HOXD11), EVX2 (an AG repeat just telomeric to the 5′ UTR of EVX2), and 5′ HOXD (a CA repeat ∼60 kb centromeric to the HOXD cluster) are three new polymorphic markers identified in the present study (details available on request). B and C, Pedigree drawings of families 1 and 2, respectively (blackened symbols represent affected individuals; arrows indicate the probands), and results of haplotype analysis. The bracketed haplotype for individual I.2 from family 1, from whom DNA was not available, was inferred from the results for individuals I.1 and II.1.