. Author manuscript; available in PMC: 2013 Dec 4.

Published in final edited form as: Toxicol Appl Pharmacol. 2010 Jun 17;247(2):10.1016/j.taap.2010.06.006. doi: 10.1016/j.taap.2010.06.006

Table 4.

Lung cancer adjusted odds ratios (OR)^a for each percentage point increase in %MMA, in analyses stratified by cystathionine synthase (CBS) polymorphism

Polymorphism	N	OR^b	95% CI
CBS rs234709 CC (wildtype)	45	0.89	0.74–1.07
CBS rs234709 CT or TT (non-wildtype)	60	1.10	0.99–1.22
CBS rs4920037 GG (wildtype)	68	1.04	0.94–1.15
CBS rs4920037 GA and AA (non-wildtype)	38	1.14	0.91–1.42

Logistic regression odds ratio where the dependent variable is lung cancer case status and the independent variable is %MMA as a continuous variable. The values given are the odds ratio and its 95% confidence interval for each 1% increase in %MMA.

Adjusted for age (≤ 65 versus > 65 years old), gender, smoking (ever versus never), and highest level of past known arsenic exposure (no well use, no measurement, 0–99 μg/L, ≥ 100 μg/L). Only includes subjects with arsenic metabolite concentrations above the detection limit.