Table 2.

Comparison in gene expression level between p53 mutant and wild-type tumors

Gene symbol	Gene title	Fold changea	Adjusted
			P-valueb
ANO1	anoctamin 1, calcium activated chloride channel	0.66	0.001
CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.32	< 0.001
CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	0.79	0.002
CACNA2D2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.47	< 0.001
CLCA2	chloride channel accessory 2	2.53	0.039
CLIC5	chloride intracellular channel 5	0.77	< 0.001
CLIC6	chloride intracellular channel 6	0.28	< 0.001
GLRB	glycine receptor, beta	0.32	< 0.001
KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	0.46	< 0.001
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	1.34	< 0.001
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.25	< 0.001
KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3	0.51	< 0.001
KCNK1	potassium channel, subfamily K, member 1	1.44	< 0.001
KCNK6	potassium channel, subfamily K, member 6	0.80	0.010
KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.65	< 0.001
KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	1.69	< 0.001
MCOLN2	mucolipin 2	1.60	< 0.001
P2RX4	purinergic receptor P2X, ligand-gated ion channel, 4	0.73	< 0.001
SCN7A	sodium channel, voltage-gated, type VII, alpha subunit	0.29	< 0.001
SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	0.71	< 0.001
TPCN1	two pore segment channel 1	0.77	< 0.001
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.72	0.005

^aFold change is calculated by dividing the mean expression of p53 mutant tumor by the mean expression of p53 wild-type tumor.

^bP-value is calculated by two-tailed t-test and adjusted by Benjamini & Hochberg correction.