Table 3.
Baseline data and biology of the intestinal subtype
|
Parameter |
INT |
NON-INT |
p |
|
|---|---|---|---|---|
| N | 39 | 159 | - | |
| Male : female |
25:14 |
77:82 |
0.079 |
|
| Age |
69 (36–81) |
67 (30–89) |
0.569 |
|
| Distant metastasis (M1) |
1 (3%) |
6 (4%) |
0.714 |
|
| Neoadjuvant therapy |
1 (3%) |
13 (8%) |
0.220 |
|
| Resection |
PPPD |
31 (80%) |
132 (83%) |
0.701 |
| Whipple |
6 (15%) |
17 (11%) |
|
|
| TPE |
2 (5%) |
10 (6%) |
|
|
| PVR |
8 (21%) |
54 (34%) |
0.105 |
|
| Perioperative mortality |
2 (5%) |
5 (3%) |
0.548 |
|
| Tumor size (mm) |
23 (1–320) |
25 (3–70) |
0.779 |
|
| Grade G3/4 |
6 (15%) |
66 (42%) |
0.002 |
|
| pT Stage 3/4 |
21 (54%) |
134 (84%) |
0.000 |
|
| pN Stage 1/2 |
16 (41%) |
116 (73%) |
0.000 |
|
| Lymph node ratio (LNR) |
.00 (.00-.58) |
.12 (.00-.86) |
0.018 |
|
| Lymphangiosis (L1) |
12 (31%) |
75 (47%) |
0.064 |
|
| Hemangiosis (V1) |
1 (3%) |
28 (18%) |
0.017 |
|
| Perineural invasion (Pn1) |
13 (33%) |
100 (63%) |
0.001 |
|
| Positive resection margin |
3 (8%) |
48 (30%) |
0.004 |
|
| Location |
PDAC / DBDAC |
16 (41%) |
133 (84%) |
0.000 |
| AMPAC / DUOAC |
23 (59%) |
26 (16%) |
|
|
| % CK7 |
85 (0–100) |
90 (0–100) |
0.070 |
|
| % CK20 |
45 (0–100) |
0 (0–100) |
0.000 |
|
| % nuclear CDX2 |
80 (0–100) |
0 (0–100) |
0.000 |
|
| Associated precursor lesion |
Adenoma |
8 (21%) |
12 (8%) |
0.016 |
| IPMN | 3 (8%) | 8 (5%) | 0.516 | |
Values are depicted as absolute and percentage of column for categorial and median (range) for scale variables, p value derived from Mann–Whitney (scale variables) or Chi squared test (categorial variables) for the respective row.
Abbreviations: Whipple / PPPD non / pylorus-preserving pancreatoduodenectomy, TPE total pancreatectomy, PVR portal venous resection, PDAC/DBDAC/AMPAC/DUOAC pancreatic ductal/distal bile duct/ampullary/duodenal adenocarcinoma, NON-/INT non-/intestinal subtype, CK cytokeratin.