Table 4.
Univariate survival analysis for tumor location and histopathological subtypes in periampullary adenocarcinomas
|
Location |
Type |
N |
Events |
Survival (months) |
p |
|
|---|---|---|---|---|---|---|
| (Deaths) | Median | Mean | ||||
| |
Comparison of tumor locations versus PDAC |
|||||
| PDAC |
ALL |
121 |
64 |
23 |
31 |
- |
| DBDAC |
21 |
14 |
29 |
39 |
0.430 |
|
| AMPAC |
40 |
14 |
64 |
72 |
0.000 |
|
| DUOAC |
9 |
6 |
71 |
46 |
0.169 |
|
| |
Comparison of tumor subtypes versus INT |
|||||
| ALL |
INT |
37 |
8 |
NR |
83 |
- |
| MIX |
12 |
8 |
30 |
37 |
0.002 |
|
| OTH WHO |
6 |
4 |
25 |
38 |
0.017 |
|
| PB |
115 |
66 |
22 |
34 |
0.000 |
|
| POOR |
21 |
12 |
13 |
28 |
0.000 |
|
| NON-INT |
154 |
90 |
22 |
35 |
0.000 |
|
| |
Comparison INT vs NON-INT stratified for tumor location |
|||||
| PDAC |
NON-INT |
111 |
63 |
20 |
29 |
0.034 |
| INT |
10 |
1 |
39 |
74 |
||
| DBDAC |
NON-INT |
17 |
12 |
12 |
37 |
0.563 |
| INT |
4 |
2 |
29 |
55 |
||
| AMPAC |
NON-INT |
22 |
11 |
38 |
56 |
0.019 |
| INT |
18 |
3 |
NR |
90 |
||
| DUOAC |
NON-INT |
4 |
4 |
4 |
10 |
0.003 |
| INT | 5 | 2 | 75 | 75 | ||
Survival estimates are derived from Kaplan-Meier method, p values from two-sided Logrank test. For Kaplan-Meier plots see Figure 3. Perioperative deaths (n = 7) were excluded from survival analysis.
Abbreviations: INT intestinal, NON-INT non-intestinal, PB pancreatobiliary subtype, MIX mixed subtype, POOR poorly differentiated carcinoma, OTH other subtypes, PDAC pancreatic ductal adenocarcinoma, DBDAC distal bile duct adenocarcinoma, AMPAC ampullary adenocarcinoma, DUOAC duodenal adenocarcinoma, NR not reached.